Born in Uruguay and raised in Colorado, Federico D'Alessandro initially aspired to be a Marvel comic book artist before discovering filmmaking as the perfect outlet for his passion for storytelling. After attending the School of Visual Arts and graduating from Loyola Marymount University's screenwriting programme, he cut his teeth storyboarding everything from indie projects to major blockbusters like I Am Legends and The Chronicles of Narnia. In 2009, he was offered a permanent position at Marvel Studios as their Lead Storyboard Artist and Animatics Supervisor, where he played a key creative role in their unprecedented run of mega hits: Thor, Captain America, Avengers, Iron Man 3 Thor: The Dark World, Avengers: Age of Ultron, Captain America: The Winter Soldier, Ant-Man, Doctor Strange, Captain Marvel, Loki, Ms. Marvel, Spider-Man: No Way Home, and the upcoming Thunderbolts.

In 2015, D'Alessandro was hired to direct TAU, a Netflix original sci-fi thriller produced by David S. Goyer and staring Gary Oldman, Maika Monroe, and Ed Skrein. It was released in June of 2018, where it became the #1 movie on the platform worldwide.