Here Comes Koume!(1999)

Koume-chan ga Iku!!

Koume is a new employee of Caramel Ribbon, Inc., a firm of designers. This is the story of her days and nights, complete with humour unique to Osaka. Seen from outside, Kansai doesn't seem like the rest of Japan. Watching this show will make you an expert, even if you know nothing about the area right now.

It's a humorous tale of life in a Japanese company, with Koume, her effeminate boss, and Kimi, a one-time girl gang member, as they try to sell (supposedly) new and fresh designs. The voice actors also come from Kansai, ensuring authenticity.

(Source: AniDB)

Note: Part of Anime no Ai Awa Awa Hour (アニメ愛のあわあわアワー), three relationship-related comedy series aimed at women that were aired on the same day.