Natalia Tsaliki (Athens, 15 September 1956) is a Greek actress.

She attended the first two semesters at the Faculty of Philosophy of the University of Athens, but dropped out. She graduated from the Drama School of the National Theatre and has since participated in many theatrical performances, initially at the National Theatre and then in various theatres in Athens. She has played roles in works by Goldoni, Molière, Shakespeare, Kretsch, Mamet, Strindberg, Chekhov, Gogol, McDonagh and others. She has taken part in several television series, as well as in two short films.