Tanjou!(1975)

Tanjou!

1. Tanjou! (誕生!)
When strictly raised teenage girl Asami becomes pregnant, she and her boyfriend decide to keep the child despite the disapproval of their parents. Meanwhile, Asami's best friend Rei discovers some secrets concerning her own background that make her feel especially connected to Asami's situation.
This manga caused controversy in its day since it dealt with the pregnancy of a high school girl.

2. Utako to Yonde Mou Ichido (詩子とよんでもういちど)
The story of a young leukemia patient and her fiancé.

3. Danshi Shikkaku (男性失格)
After surviving a strange accident, a young man starts gradually turning into a woman.